Endocrine Abstracts

Mildronate, a γ-butyrobetaine analogue is actually used as an antiischemic drug. It was also shown to have effect on mechanisms of glucose utilization.Methods: Diabetes mellitus in Wistar rats was induced by injection of streptozotocin (50 mg/kg). Experimental rats were treatment with Mildronate (100 mg/kg daily, per os) for 6 weeks. Weight, blood glucose concentration, blood triglyceride concentration, blood ketone body concentration, glycat...

BackgroundCardiac autonomic neuropathy (CAN) is a serious complication of diabetes mellitus (DM) that is strongly associated with increased risk of cardiovascular mortality. The significance of CAN has not been fully appreciated. Treatment of CAN includes physical activity.AimTo detect CAN status and measure the influence of physical activity on the autonomic nervous system using cardiovascular autonomic refl...

Background: Inflammation is involved in the pathogenesis of complications of type 1 diabetes (T1DM). We aimed to assess the differences in the markers of endotoxaemia and faecal calprotectin in patients with T1D different status of diabetic kidney disease (DKD).Methods: 31 generally healthy adults (control) and 74 patients with T1DM and were included. Of the latter, 13 had DKD (defined as microalbuminuria, macroalbuminuria, estimated glomerular filtratio...

Background: Diabetic retinopathy (DR) is one of the most common complications resulting from uncontrolled diabetes mellitus (DM). DR is the leading cause of blindness and low vision. DR is usually diagnosed at an advanced stage, so despite the individual treatment, it is only possible to slow down the progression of DR. Therefore, new potential biomarkers are needed for an earlier DR prognosis to prevent the development of DR. According to the latest studies, ubiquitin-proteas...

Background: Diabetic retinopathy is a common complication of diabetes mellitus and the leading cause of blindness in the working-age population in the developed world. Novel biomarkers are needed to improve the screening efficiency for the prevention and early treatment of this condition. Accumulation of advanced glycation end products (AGEs) is considered as one of pathogenetic pathways in development of diabetic complications. AGEs are formed in the process of non-enzymatic ...

Background and aim: The role of derangements of nitric oxide (NO) metabolism in the pathogenesis of complications of type 1 diabetes mellitus (T1D) is not sufficiently clear. There is little data on simultaneous measurements of NO metabolites nitrite and nitrate (NO2/NO3) in urine and serum in T1D. Data about the measurement of NO production by electronparamagnetic spectroscopy (EPR) in whole blood in T1D were never published. To fill this gap we have cha...

Background: Physical activity is the first-line treatment in type 2 diabetes. Interval walking training has demonstrated good tolerability and more pronounced positive effects on physical fitness and metabolism in type 2 diabetes, compared to continuous walking. However, the effects of interval walking on vascular health markers, such as albuminuria, has not been extensively studied. Type 2 diabetes is associated with derangements in leptin/adiponectin axis, which might predis...

Introduction: Diabetic nephropathy is a major complication of diabetes mellitus. Involvement of abnormal nitric oxide (NO) production, both via nitric oxide synthase (NOS) dependent and independent pathways (for example, xantine oxoridoreductase (XOR)) has been discussed. New compounds to treat diabetic nephropathy are searched intensively, some novel dihydropirine class drugs (DHP) have been proposed for this purpose.Aim: To study the changes in NO conc...

Introduction: A possible involvement of proteasomes in the pathogenesis of type II diabetes mellitus has been recently reported. Therefore, association of polymorphism of proteosomal genes with type II diabetes mellitus is of particular interest. In this study, molecular markers of the proteasomal alpha subunit 6 gene PSMA6 and its adjacent genomic sites have been analyzed.The goal of this study was to characterize polymorphisms of the HSMS801, HSMS702, ...

Background: Hypoxia, oxidative stress and inflammation induced by hyperglycaemia are ‘key players’ in development of diabetic complications.Aim: To analyze differences in levels of nitric oxide (NO) and its metabolites nitrate and nitrite (NO2/NO3) and well as angiopoietin 2 (Ang2) and neuropeptide Y (NPY) in patients with type 1 diabetes and different complications status; to analyze associations between these markers.Me...